Enhancement of solubility of leflunomide with β-cyclodextrin inclusion complexation
Mahaparale P. R.1*, Thorat V. P.2
1Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, 431005.
2Siddhi College of Pharmacy, Chikhali, Pune, Maharashtra, 411062.
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 30 April, 2021.
Leflunomide is a Non-steroidal Anti-Inflammatory drug, which is poorly water soluble. In present study attempt has been made to prepare and characterize inclusion complexes of drug with Beta Cyclodextrin (β-CD). The phase solubility analysis indicated the formation of a 1: 1 molar inclusion complex of drug with β-CD. Apparent stability constant (KC) was 674 K−1 for β-CD complex. The inclusion complexes were prepared by three different methods viz. coprecipitation, kneading and microwave irradiation method. The prepared complexes were characterized using dissolution study, FTIR and X-ray diffractometry. The inclusion complex prepared with β-CD by kneading method exhibited greatest enhancement in solubility (18 mg/100ml) and fastest dissolution (T90 = 29 min.) of Leflunomide.
Leflunomide, Inclusion complex, βCD, Enhancement in solubility.