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Year : 2021, Volume : 14, Issue : 2
First page : ( 787) Last page : ( 792)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00137.2

Chemopreventive potential of adrenergic blocker in behavioral stress accelerated prostate cancer development in rats

Nargatti Prakash1*, Patil Sudhir2, Patil Sandip34, Naikwade Nilofar2

1Department of Pharmacology, Annasaheb Dange College of Pharmacy, Ashta, Sangli, Maharashtra, India.

2Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

3Department of Pharmacology, Dr. Shivajirao Kadam College of Pharmacy, Kasbe Digraj, Sangli, Maharashtra, India

4Biocyte Institute of Research & Development, Sangli, Maharashtra, India

*Corresponding Author E-mail: prakashnargatti@gmail.com

Online published on 30 April, 2021.


Psychosocial stress increasingly recognized as an important health issue in development and progression of cancer. Prostate cancer patients have increased levels of stress and anxiety. Several studies suggest that environmental factors are important in prostate cancer development. Patients with prostate cancer reportedly show higher levels of anxiety compared with other cancer patients. Based on psychoneuroimmunology we report that stress promotes prostate cancer in rats through stress response system. The sympathetic nervous system potentially regulate tumour α and β-adrenergic signalling both via circulating adrenaline/nor-adrenaline and via local nor-adrenaline release from SNS nerve fibres. Activation of the sympathetic nervous system promotes cancer progression via β-adrenoreceptor-mediated activation of protein kinase A and exchange protein activated by adenylyl cyclase signalling pathways. Stimulation of α receptor leads to the activation of Ca++ permeable no selective cationic channels and transient receptor potential (TRP) channel family, which are responsible for cell proliferation, which leads to prostate cancer progression. Certain adrenergic blockers can exert anticancer activity by blocking α and β adrenergic pathway. Thus current study examined association between prostate cancer progression and behavioural study. Our findings could be used to new clinical and treatment strategies in cancer therapy.



Stress, Cancer, Signalling pathway, Kinase A, TRP channel family.


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