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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 2
First page : ( 775) Last page : ( 778)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00135.9

Green synthesis of silver nanoparticles using Symplocos racemosa and its antifungal activity against Candida albicans

Fathima Tahreem1, Rajeshkumar S.1*, Nagalingam M.2

1Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai-600077, Tamil Nadu, India.

2Department of Biochemistry, Indo-American College, Cheyyar, Thiruvannamalai-604407, Tamil Nadu, India.

*Corresponding Author E-mail: ssrajeshkumar@hotmail.com

Online published on 30 April, 2021.

Abstract

Aim: To determine the synthesis of silver nanoparticles of Symplocos racemosa and its antifungal activity on Candida albicans. Introduction: Fungi has the ability to adapt any stress condition and accordingly production of virulence factor and encrypting gene arrangements, gives some of them a unique ability to develop resistance against traditional fungicides up roaring for an effective and immediately strategy against fungal pathogens. The vast majority of nano-sized agents are metal nanoparticles such as zinc oxide, titanium dioxide, magnesium oxide or silver nanoparticles. They are attractive especially due to their small size, large surface to volume ratio, chemically altered physical properties, unique electrical, thermal and mechanical features. Candidiasis refers to an infection of skin, mucosa and rarely of the internal organ caused by yeast like fungus Candida albicans. Symplocos racemosa also called as lodhra belongs to family symplocaeae. The important chemical constituents of S. racemosa are flavonoids, tannins, loturine, loturidine and collotourine. Materials and Methods: Preparation of plant extract is done by collection of plant extract in the form of powder. The prepared nanoparticles analysed for its antimicrobial activity against oral pathogens. Results and Discussion: Normal value of zone of inhibition of bacteria for antibiotics was compared with zone of inhibition of each microorganism. The results from this study proved that Symplocos racemosa plant extract acts as an antifungal and antibacterial agent. Conclusion: The research proves that silver nanoparticles of Symplocos racemosa has efficiently worked against Candida albicans which promotes the capability of Symplocos racemosa plants to be used as herbal remedies to treat fungal pathogens.

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Keywords

Candida albicans, Symplocos racemosa, Silver nanoparticles, Antifungal activity.

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