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Year : 2021, Volume : 14, Issue : 2
First page : ( 752) Last page : ( 756)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00131.1

Formulation and evaluation of carvedilol sustained release capsules by semisolid matrix filling technique

Priyanka P.1, Harika S.2, Wajid MD.3, Kumar Y. Shravan4*

1Department of Pharmaceutics, Vaagdevi College of Pharmacy Affiliated by Kakatiya University, Warangal, 506003, India

2Vaagdevi Institute of Pharmaceutical Sciences, Affiliated by Kakatiya University, Telangana, Warangal, 506003, India.

3Vaagdevi College of Pharmacy Affiliated by Kakatiya University, Telangana, Warangal, 506002, India

4Department of Pharmaceutics, Vaagdevi College of Pharmacy, R&D Head Magnificent Cosmo Cosmoceuticals, Telangana, Warangal, 506003, India.

*Corresponding Author E-mail: shravanyamsani@gmail.com

Online published on 30 April, 2021.


The objective of the study was to prepare semisolid capsules of poorly water-soluble drug Carvedilol using a combination of technologies involving solid dispersion preparation and converting it into semisolid matrix filled in hard gelatin capsule. Different excipients like Gelucire44/14, poloxamer188, gelatin, PVPK30, PEG6000 were used. Fifteen capsule formulations were prepared and assessed for their release characteristics. Lipid matrix formulations prepared with increasing amount of polymer showed a substantial decrease in release rate of drug in case of poloxamer188Whereas gelucire 44/14, gelatin, PVPK30, and PEG6000 showed immediate release the mechanism of drug release from the test formulations were studied. The possible modification of carvedilol release kinetics by using poloxamer in the SSM was studied. results indicate that poloxamer188 is an appropriate carrier for the development of sustained release drug delivery systems and Gelucire44/14 a highly hydrophilic and lipophilic balance (HLB) excipient, acts as release enhancer in the different ratios studied. Among all the formulations Carvedilol formulation with poloxamer188 in the ratio of (1: 3) showed sustained release. Release kinetics studies were performed. The formulation with poloxamer in 1: 3 ratio follows first order and Higuchi order release kinetics governed by Fickian diffusion mechanism with R2 value 0.992.



Carvedilol, Gelucire44/14, Poloxamer188, Gelatin, PVPK30, PEG6000.


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