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Year : 2021, Volume : 14, Issue : 2
First page : ( 747) Last page : ( 751)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00130.X

Proliposome technique for enhancement of bioavailability of metformin hydrochloride

Das Saumya1*, Jithan A.V2, Guptha C. Raghunadha3, Pattanayak Dharmajit1

1Bengal School of Technology, Sugandha, West Bengal.

2Omega College of Pharmacy, Hyderabad

3Pellets Pharma Ltd, Hyderabad

*Corresponding Author E-mail: saumyaranidas@gmail.com

Online published on 30 April, 2021.


The aim of the present study was to develop and characterized a vesicular drug carrier system (proliposome) for oral delivery of metformin hydrochloride to overcome the problems related with conventional drug delivery system. Proliposomes of metformin hydrochloride were prepared by spray gun technique by varying the composition drug and excipiets. Proliposome formulations were characterized for compatibility, Vesicle size, % Drug content, % Entrapment efficiency, Surface morphology, Surface charge, in vitro drug release and stability studies. The proliposomal dry powder was prepared for optimized proliposomal formulation MPF9. Drug and physical mixture were characterized by FTIR, the result of FTIR study showed that no interaction between drug and polymers and other formulation parameters of formulated proliposomes and proliposomal dry powder are evaluated which showed better results.



Proliposome, Metformin hydrochloride, FTIR, In vitro drug release.


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