Users online: 4528    [ij] [ij] [ij] 
Email id

Year : 2021, Volume : 14, Issue : 2
First page : ( 741) Last page : ( 746)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00129.3

Determination of pravastatin sodium by analytical Spectrophotometry

Antakli Saad*, Nejem Leon, Kullah Ahmad

Department of Chemistry, Faculty of Science, University of Aleppo, Syria.

*Corresponding Author E-mail antakli@scs-net.org

Online published on 30 April, 2021.


Simple and rapid spectrophotometric method for the quantitative analysis of Pravastatin sodium (PVS) in raw material and tablets pharmaceutical formulation has been described. The method is based on the formation of yellow ion-pair complex between Pravastatin sodium and Bromocresol purple in Acetonitrile medium. Different parameters affecting the reaction such as: effect of solvents, time, reagent concentration, correlation ratio, etc. were optimized. The formed complex was quantified spectrophotometrically at absorption maximum at 389nm. Linearity range was 2.23–26.79μg/mL, regression analysis showed a good correlation coefficient R2 = 0.9997. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.158μg/mL and 0.479μg/mL respectively. The average percent recovery was found to be (99.16–100.00)% for Pravastatin sodium. This study was applied on Syrian pharmaceutical trademark: (PRAVASTATIN-ELSaad 20). The method was successfully applied for the determination of pravastatin sodium in tablets pharmaceutical formulation. The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis.



Pravastatin sodium, Bromocresol purple, Spectrophotometric method.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
624,534,819 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.