Users online: 3600    [ij] [ij] [ij] 
Email id

Year : 2021, Volume : 14, Issue : 2
First page : ( 735) Last page : ( 740)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00128.1

The effect of ethyl cellulose 10 Cps on the floating characteristic and ranitidine HCL release from floating tablet (using HPMC K15M Matrix)

Su'udiyah Unun Faiz, Sugiyartono*

Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Airlangga Jl., Dharmawangsa Dalam 4–6Surabaya, Indonesia

*Corresponding Author E-mail: sugiyartono100@gmail.com

Online published on 30 April, 2021.


Ranitidine HCl is one group of H2-blockers that is normally used for the therapy of upper digestive tract. Ranitidine absorption occurs only in the gastric and initial part of intestine. In addition, ranitidine also undergoes metabolism in the colon, therefore it has a low bioavailability. According to that, a drug delivery system that maintains preparation in the gastric to increase absorption in the gastric in order to increase bioavailability is needed. The tablet was made using wet granulation method with HPMC K15M as the matrix by adding ethyl cellulose 10 cps to inhibit the release of ranitidine. This is because as a drug, HPMC K15M will increase the release of ranitidine HCl. The tablet produced was evaluated for its floating property and release using the medium of HCl 0.1N at 37°C for 8 hours using type II dissolution test equipment. The test results proved that the tablet produced has a good floating property and with a decrease in the concentration of ethyl cellulose, it will increase the release of ranitidine HCl.



Ranitidine HCl, Floating tablet, HPMC K15M, Ethyl cellulose 10 cps.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
625,982,051 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.