Using 24 factorial designs optimization of repaglinide gastroretentive drug delivery system
Ramu B.1*, Dr. Chandrul Kaushal K.2, Dr. Pandiyan P. Shanmuga3
1Research Scholar, Mewar University, Gangrar, Chittorgarh, Rajasthan-312901, India.
2Research Supervisor, Dean and Professor, Department of Pharmaceutical Sciences, Mewar University, Gangrar, Chittorgarh, Rajasthan-312901, India.
3Research Co-Supervisor, Department of Pharmacy, Mewar University, Gangrar, Chittorgarh, Rajasthan-312901, India
*Corresponding Author E-mail:
Online published on 30 April, 2021.
Objective: Floating tablets of repaglinide were developed using hydrophilic polymers like HPMC (hydroxy propyl methyl cellulose) K4M, HEC (hydroxy ethyl cellulose) and Chitosan to control the water uptake and effervescent agent, NaHCO3(sodium bicarbonate) used for buoyancy of the system, to prepare a stable formulation and to prolong gastric residence time leading to an increase in drug bioavailability. Method: Tablets are prepared by direct compression technique using polymers Chitosan, HPMC K4M, HEC, and sodium bicarbonate. In-vitro floating properties, and In-vitro drug release. Gastro retentive drug delivery systems were optimized by 24 factorial designs of four variables at two levels. Results: Tablets were evaluated for their physical characteristics viz., hardness, thickness, friability and weight variation, drug content and floating properties. The best formulation subjected for kinetic treatment. i.e., zero order, first order, peppas, Higuchi, and Hixon Crowell. Conclusion: Repaglinide floating tablets was successfully optimized by using 24 factorial design and HPMC K4M, HEC, Chitosan were used as retarding materials for controlling the drug release. Sodium bi carbonate was helped to maintenance the gastro retentive system density. The optimized formulation (F16) was followed the fickian diffusion of drug release the reproducible drug release kinetic values were indicating that, this method of preparation is acceptable.
Repaglinide, Floating tablets, Gastroretentative drug delivery system.