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Year : 2021, Volume : 14, Issue : 2
First page : ( 623) Last page : ( 627)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00111.6

Biological activity against Staphylococcus aureus of Isolated from raisins containing protocatechuic acid

Saeed Mohammed Khaleel*, Najim Saja Ayad, Salman Noor Sabah, Abdulbaqi Saad Saleem, Jawad Farah Ghassan

Directorate of Materials Research, Ministry of Science and Technology, Baghdad, Iraq

*Corresponding Author E-mail: mohkh66@gmail.com

Online published on 30 April, 2021.


Staphylococcus aureus infection is a frequent cause of human sepsis, it is an infection linked with high mortality and without specific intervention. When they exist in human or animal plasma, staphylococci are known to agglutinate, however the bacterial agents responsible for agglutination and their possible contribution to disease pathogenesis have not yet been revealed. There are various edible plants possesses different pharmacological activities one of them Raisins, which contained Protocatechuic acid (PCA), a simple phenolic acid. High performance liquid chromatography (HPLC) was used to determine (PCA) in the phenolic compounds. The aim of broth and agar dilution methods is to determine the lowest concentration of the assayed antimicrobial agent (minimal inhibitory concentration, MIC) that, under defined test conditions, inhibits the visible growth of the bacterium being investigated concentration was (125, 312, 625, 1250, 2500) μg/ml. The highest inhibitory effect observed was (Livoflaxcin, Ciproflaxacin, Tigacyclin, Nitrofurantation, Vancomycin). Thus revealing the potential of these extracts as possible alternatives for use in the food and/or pharmaceutical industries. The aim of this study was to evaluate the antibacterial activity of Raisin extract containing protocatechuic acid against Gram-positive bacterial strains (Staphylococcus aureus), isolated from clinical samples.



Protocatechuic acid, Staphylococcus aureus, Antibacterial activity.


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