Users online: 3902    [ij] [ij] [ij] 
Email id

Year : 2021, Volume : 14, Issue : 2
First page : ( 599) Last page : ( 604)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00107.4

Antimicrobial activity of curcumin analog PGV-6, HGV-6 and GVT-6

Ritmaleni13*, Sardjiman13, Purwantini Indah2

1Department of Pharmaceutical Chemistry, Gadjah Mada University, Yogyakarta, Indonesia.

2Department of Biological Pharmacy, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia

3Curcumin Research Center, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia.

*Corresponding Author E-mail: ritmaleni@ugm.ac.id

Online published on 30 April, 2021.


PGV-6, HGV-6 and GVT-6 are three among curcumin analogs that successfully synthesized. These analogs have a monoketone on their structure. They have two kind of substituents on their aromatic rings, chloro-and hydroxyl-group. According to SAR analysis, these compounds will have a very good activity as antimicrobial agents. This research is aimed to study the antimicrobial activity of those three compounds by using micro-dilution method. Synthesis of PGV-6, HGV-6 and GVT-6 are carried out by using the aldol condensation reaction between a keton (cycopentanone, cyclohexanone, acetone) and aromatic aldehyde (3, 5-Dichloro-4-hydroxybenzaldehyde) in acid condition. First work was to see the inhibition percentage and the second experiment is to see the lowest sensitivity against microbes (bacteria and fungi), of three compounds by using micro-dilution method. From the results, it was obtained that the antimicrobial test against seven bacteria and one fungus, showed that PGV-6 only inhibits the growth of Staphylococcus aureus (SA) bacteria; HGV-6 inhibits Klebsiella pneumonia (KP), Escherichia coli (EC), Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA) bacteria; GVT-6 inhibits the growth of Klebsiella pneumonia (KP), Escherichia coli (EC), Staphylococcus aureus (SA), Streptococcus faecalis (SF) bacteria. None is active against Candida albicans (CA) fungi. GVT-6 is still sensitive against bacteria at 250 μL/mg of the concentration. GVT-6 is promising to be more developed as antimicrobial agents as confirmed by its docking study.



Curcumin analog, PGV-6, HGV-6, GVT-6, Antimicrobial, Bacteria, Fungi.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
623,014,462 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.