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Research Journal of Pharmacy and Technology
Year : 2021, Volume : 14, Issue : 12
First page : ( 6496) Last page : ( 6502)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2021.01123

In-vitro Antioxidant and Antihyperglycemic effect of Muntingia calabura L. fruit extracts

Sowmya S.1, Jayaprakash A.2*

1Research Scholar, PG and Research Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur-635601, Tirupattur District, Tamil Nadu, India

2Assistant Professor, PG and Research Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur-635601, Tirupattur District, Tamil Nadu, India

*Corresponding Author E-mail: jpsacred2019@gmail.com

Online Published on 02 March, 2022.

Abstract

This study investigated the in-vitro antioxidant activity and antidiabetic effect of Muntingia calabura fruit extract by in-vitro α-amylase and α-glucosidase inhibitory activity. Muntingia calabura fruit was extracted with aqueous methanol by soxhlet extraction. The total phenols and total flavonoids contents were estimated and evaluated for antioxidant activities (DPPH, ABTS) and in-vitro antidiabetic activity by measuring their inhibitory activity on α-amylase and α-glucosidase levels. The findings showed that the fruit extract had high content of total phenol and exhibited moderate free radical scavenging activity. The fruit extract showed inhibitory effect on α-amylase [IC50Value =61.43 g/mL] and α-glucosidase [IC50 Value=140.33 g/mL] compared to standard acarbose. The fruit extract can be used as a potential source for the development of new hypoglycemic agents may be due to the presence of high phenol content.

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Keywords

Muntingia calabura, Phytochemicals, Antioxidants, α-amylase and α-glucosidase.

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