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Research Journal of Pharmacy and Technology
Year : 2021, Volume : 14, Issue : 11
First page : ( 6049) Last page : ( 6054)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2021.01051

Analytical method development and validation for telmisartan, chlorthalidone and amlodipine by uv- spectroscopic method.

Sanap Rutuja M.1*, Wavhale Sarika R.1, Kunjir Vaibhavi V.1, Shete Rajkumar V.2

1Department of Pharmaceutical Quality Assurance, Rajgad Dnyanpeeth's College of Pharmacy, Bhor-412206 Dist- Pune (Maharashtra) India

2Department of Pharmacology,Rajgad Dnyanpeeth's College of Pharmacy, Bhor-412206 Dist-Pune (Maharashtra) India

*Corresponding Author E-mail: rutujasanap2311@gmail.com

Online Published on 22 February, 2022.

Abstract

A simple, sensitive and accurate UV- spectrophotometric absorption correction method has been developed for simultaneous determination of Telmisartan, Amlodipine and Chlorthalidone in combined tablet dosage form. Analytical method development and validation plays important role in the discovery manufacture of pharmaceuticals and development. In this paper, absorption correction method is used for multi-component analysis. The wavelengths selected for the analysis were 311nm for Telmisartan, 228nm for Chlorthalidone and 253nm for Amlodipine. Beer's law obeyed the concentration range of 2–10 µg/ml, 2–10 µg/ml and 5–25 µg/ml for Telmisartan, Amlodipine and Chlorthalidone. Methanol is used as a solvent. The accuracy of the method was assessed by recovery studies and was found between the range of 100% to 110% for Telmisartan, 85% to 110% for Amlodipine and 85% to 105% Chlorthalidone. The % RSD value was found to be less than 2. Thus, the method was simple, precise, economic, rapid, accurate and can be successfully applied for simultaneous determination of Telmisartan, Amlodipine and Chlorthalidone in combined tablet dosage form.

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Keywords

Telmisartan, Amlodipine, Chlorthalidone, UV- Spectrophotometer, Validation.

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