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Research Journal of Pharmacy and Technology
Year : 2021, Volume : 14, Issue : 10
First page : ( 5573) Last page : ( 5578)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2021.00971

Spermatogenic and Leydig Cells Induced Hyperlipidemia: A Review

Widhiantara I Gede1*, Permatasari Anak Agung Ayu Putri1, Yasa I Wayan Putu Sutirta2

1Department of Biology, Faculty of Health and Science, University of Dhyana Pura, Badung, Bali, Indonesia, 80361

2Department of Clinical Pathology, Faculty of Medicine, University of Udayana, Denpasar, Bali, Indonesia, 80232

*Corresponding Author E-mail: widhiantara@undhirabali.ac.id

Online Published on 22 February, 2022.


Lipids are macromolecules that are very important in cell metabolism. Dietary changes and tendency to consume foods high in fat causes hyperlipidemia that increase the risk of various blood vessel abnormalities to the reproductive system. In men, normal reproductive function is closely related to the presence of the testes with the cells in them and the normal secretion of the hormone testosterone. There have been many studies on male experimental animals using high fat induction which prove that there is high fat in the circulatory system which results in metabolic and physiological disorders in the body, especially enzymes related to reproductive function, decreased secretion of reproductive hormones and abnormal structure of spermatozoa cells and degeneration of Leydig cells. Therefore, this review provides a review of the effect of high fat diets on reproductive cells, especially spermatogenic cells and Leydig cells.



Hyperlipidemia, Spermatogenic cells, Leydig cells, High-fat diet.


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