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Research Journal of Pharmacy and Technology
Year : 2021, Volume : 14, Issue : 10
First page : ( 5385) Last page : ( 5390)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2021.00939

A Nutraceutical approach to enhance Reproductive longevity and Ovarian health using Curcuma longa in wistar Rats

Gowda K M Damodara1, Moodithaya Shailaja S1*, Kedilaya Vishakh R2, Nayanatara A K3, Kumari N Suchetha4

1Dept of Physiology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore - 575018, Karnataka, India

2Central Research Laboratory, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore - 575018, Karnataka, India

3Department of Physiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

4Dept of Biochemistry, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore - 575018, Karnataka, India

*Corresponding Author E-mail: shailaja.moodithaya@nitte.edu.in

Online Published on 22 February, 2022.

Abstract

Aging is associated with various physiological, pathological and psychosocial alterations. This study evaluates the benefits of Curcumin by assessing reproductive aging indices and ovarian health in Wistar rats. Laboratory bred adult rats selected for the experiment. After 12 months of follow-up. The animals were grouped into Normal control rats, Sham control group, Curcumin-1(100 mg/kg body weight), Curcumin-2(200 mg/kg body weight) and Curcumin-3 (400 mg/kg body weight). For the duration of six months Curcumin dosage was administered. The experimental parameters included estrous cycle and histological evaluation of ovarian follicles. Data were analyzed using one-way ANOVA. The percentage of primordial follicles was significantly more (p<0.001) in all the groups when compared with other types of follicles. Prolonged increase (p=0.0001) in the Diestrus phase in animals treated with different dosages of Curcumin. The current study concludes that Curcumin, an active component of Curcuma longa contributes to the anti-aging properties.

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Keywords

Curcumin, Anti-aging, Estrous cycle, Reproductive aging, Ovarian aging, Ovarian follicles.

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