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Research Journal of Pharmacy and Technology
Year : 2021, Volume : 14, Issue : 10
First page : ( 5355) Last page : ( 5358)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2021.00934

The Anti-Diabetic and Anti-Hyperlipidemia effect of Citrus maxima Fruit Peel extract in Streptozotocin - Induced Diabetic Rats

Mohammed Shaimaa M.1*, Abd-Almonuim Afnan E.2, Majeed Ahmed3, Khlaf Haithm4

1Ph.D. Clinical Chemistry, Al-Mustaqbal University College, Babylon, Iraq

2Ph.D. Inorganic Chemistry, Al-Rasheed University College, Baghdad, Iraq

3MSc. Pharmacology and toxicology, Al-Mustaqbal University College, Babylon, Iraq

4MSc. Biochemistry, Faculty of Pharmacy, Al-Israa University, Amman, Jordan

*Corresponding Author E-mail: shaimaa77munther@gmail.com

Online Published on 22 February, 2022.


The ethanol extract of Citrus maxima fruit peel was evaluated for its hypoglycaemic and hypolipidemic activity in normal and Streptozotocin (STZ)-induced diabetic rats, using fasting and glucose tolerance test measurements. Experiments were performed using Thirty-Two Male Wister albino rats randomly divided into 4 groups and each group have 8 animals. Group1 assigned as a control injected with normal saline only. Group 2 assigned as a diabetic control injected with Streptozotocin 50mg/Kg, Group 3 assigned for diabetic + Citrus maxima in a dose of 400mg/Kg, Group 4 is assigned for the diabetic + Citrus maxima in a dose of 600mg/Kg. The Streptozotocin is injected intraperitonially to all animal in the groups except the control group. Blood samples were collected from animal before and at 21th day end of the study period. Body weight, blood glucose, serum total cholesterol (TC), triglyceride (TG), and HDL cholesterol were analysed using diagnostic kits. Serum was separated from blood samples collected. In addition oral glucose tolerance test was performed in overnight fasted control animals. Results showed that Citrus maxima extract possesses significant antidiabetic activity against streptozotocin induced diabetic rats by decreasing blood glucose levels, maintaining body weight, and serum lipid concentrations to approximate normal level. Furthermore, the extract of the title plant possesses dose dependent antidiabetic activity.



Diabetes, Glucose tolerance, Citrus maxima fruit peel, Streptozotocin.


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