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Year : 2021, Volume : 14, Issue : 1
First page : ( 552) Last page : ( 554)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00100.1

A comprehensive review on pancreatic cancer

Jagadeesan B.1, Haran P. Hari1, Praveen D.2, Chowdary P. Ranadheer2, Aanandhi M. Vijey1*

1Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India.

2Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India.

*Corresponding Author E-mail: hodpchemistry@vels.univ.ac.in

Online published on 22 April, 2021.


Pancreatic cancer is characterized as a fatal disease where the healthy cells of the pancreas stops functioning and undergoes uncontrollable cell division. Three types of pancreatic tumors are in existence. They are pancreatic neuroendocrine tumor, pancreatic ductal adenocarcinoma and exocrine tumor. Pancreatic cancer stands in the 14th position in causing the most general cancer. In India, the pancreatic cancer incidence is measured at a low point i.e. (0.5–2.4 per 100000) in males and (0.2–1.8 per 100000) in females. Diabetes, smoking habit, excessive alcohol consumption for prolonged years, cholecystectomy, gastrectomy and low intake of fruits and vegetables are considered to be the major risk factors. Smoking termination will be the powerful action to decrease the opportunity of pancreatic cancer. Pancreatitis will lead to the pancreatic cancer. Pancreatitis and diabetes acts as a background disease in the pancreatic cancer. To diagnose pancreatic cancer, Computed Tomography, Magnetic Resonance Imaging technique acts as a first-line and second-line techniques respectively. Surgical treatment is the only treatment believed to be producing the potential cure, with the combination of chemotherapy. The medications prescribed as per USAD are Capecitabine, 5-Flurouracil, Irinotecan, Leucovorin, Oxaliplatin, Nab-paclitaxel. Pancreatic cancer is recognized as life threatening disease in both developed and developing countries.



Pancreatic cancer, Surgical treatment, Endocrine tumor, Pancreatitis.


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