A review on enzyme activated drug delivery system Ahad Hindustan Abdul1*, Haranath Chinthaginjala1, Vikas Srikantham Sai2, Varam Naga Jyothi1, Ksheerasagare Tarun1, Gorantla Surya Prakash Reddy1 1Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu-515721, Andhra Pradesh, India. 2Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu-515721, Andhra Pradesh, India. *Corresponding Author E-mail: abdulhindustan@gmail.com
Online published on 22 April, 2021. Abstract Enzymes are the bio-molecules that are present in the various sites of the body and are specific in the organs. The recent trend of drug delivery as nanoparticles has a handful of uses. The designing of the systems in small-sized particles like nanoparticles have merits as they can easily diffuse into the membrane through the intracellular pores of very small size. Such a kind of delivery system has its applications in various treatments, one of which is in cancer therapy. Even though the anti-neoplastic drugs are much potent, they may also act on the normal cells and thus inhibiting the normal physiological process leading to serious adverse effects. Such a kind of problem can be overcome by the enzyme activated drug delivery system (EADDS). An enzyme activated system, the discharge of drugs from the system is activated by the enzymatic process. Various approaches for enzymatic drug delivery include liposomes, nanoparticles, prodrug, microparticles, etc. The main components in this system are drug, nanocarrier, promoiety, coating polymer, ligand, etc. The present review is about to provide some ideology on how the drug can be delivered to a particular type of organ or site based on the presence of respective enzyme. Top Keywords Enzyme, Bio-catalysts, Nanocarriers, Targeted delivery, Ligand. Top |