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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 466) Last page : ( 470)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00085.8

Design, synthesis, characterization of antimicrobial activity of schiff bases of novel quinazolin-4-one derivatives

Kavitha K1*, Mohan S.1, Srinivasan N.2, Suresh R.2

1Department of Pharmaceutical Chemistry, Karpagam College of Pharmacy, Ottakalpandapam, Coimbatore, Tamil Nadu.

2Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Tamil Nadu.

*Corresponding Author E-mail: kavithakrocks@gmail.com

Online published on 22 April, 2021.

Abstract

Some novel Schiff bases of quinazolin-4-(3H)-one were synthesized in good yields and evaluated for their possible anti-bacterial, anti-fungal activities. The structures of the newly synthesized compounds were confirmed by their spectrum of IR, NMR, and MASS. Their antibacterial, fungal activities were evaluated by Plate hole diffusion method against gram positive, gram negative bacteria and Aspergillus Niger, candida albicans were used. The newly synthesized compounds showed moderate to significant anti-bacterial and fungal activities when compared to standard drug. The obtained results showed that the most active compounds could be useful as a template for future design and modification, investigation to produce more active pharmacophores.

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Keywords

Quinazolin-4-one, Schiff base, Para amino phenol, Anti-microbial activity, Aromatic aldehydes.

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