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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 450) Last page : ( 454)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00082.2

In vitro antimicrobial and antitubercular screening of newly synthesized Mercaptobenzimidazole-clubbed chalcone derivatives

Kardile Deepak*, Shirsat Mrunal

Department of Pharmaceutical Sciences, Madhav University, Pindwara-307026, Rajasthan, India

*Corresponding Author E-mail: kardiledeepak@gmail.com

Online published on 22 April, 2021.

Abstract

In this present investigation to studies of mercaptobenzimidazole-clubbed chalcone derivatives was efficiently synthesized, which is further characterized with the help of thin layer chromatography, spectroscopy techniques such as FTIR and 1HNMR. The newly synthesized derivatives were examined against in vitro antimicrobial and antitubercular activities. The result revealed that the titled compounds an average antibacterial activity against gram-positive Bacillus subtilis, gram-negative Escherichia coli as compared to standard ciprofloxacin. Compounds DPK4B2d2, DPK4B2d3, DPK4B2d4 and DPK4B2d6 shown potent antifungal activity against Aspergillus niger as compared to standard fluconazole. Antitubercular activity of the synthesized compounds examined against Mycobacterium tuberculosis, compounds DPK4B2d1 and DPK4B2d2 shown potent activity in the comparison of standard such as Pyrazinamide, Ciprofloxacin, and Streptomycin.

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Keywords

Mercaptobenzimidazole, Chalcone, Antimicrobial, Antitubercular.

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