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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 445) Last page : ( 449)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00081.0

Determination of montelukast by new spectrophotometric method using bromocresol green

Sarkis Nazira1, Antakli Saad2, Alhamada Zakaa1

1Department of Analytical and Food Chemistry, Faculty of Pharmacy, Aleppo University, Syria.

2Department of Chemistry, Faculty of Science, Aleppo University, Syria.

*Corresponding Author E-mail: nazirasarkis@gmail.com

Online published on 22 April, 2021.

Abstract

Simple, sensitive and accurate spectrophotometric method has been developed for the determination of Montelukast Sodium in raw and tablets formulation. The method is based on the formation of yellow ion-pair complex between Montelukast Sodium and Bromocresol green in Dichloromethane medium. The absorption maximum of the complex was found to be at 405 nm. Different parameters affecting the reaction such as: effect of solvents, reagent concentration, correlation ratio, etc. were carefully studied and optimized. The formed complex was quantified spectrophotometrically at absorption maximum. Linearity range was 2–19 μg/mL, regression analysis showed a good correlation coefficient R2 = 0.9998. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.50 μg/mL and 1.51 μg/mL. The developed methods could be successfully applied to pharmaceutical formulations. The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis.

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Keywords

Montelukast Sodium, Bromocresol Green, Spectrophotometric method.

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