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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 427) Last page : ( 431)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00077.9

Formulation of oral dosage form of antidiabetic drug glipizide using mixed solvency method

Preeti*, Swarupanjali Padhi

Pharmacy Institute, Noida Institute of Engineering and Technology, 19 Knowledge Park-II, Institutional Area, Greater Noida, U.P-201301.

*Corresponding Author E-mail: singhpreeti2308@gmail.com

Online published on 22 April, 2021.

Abstract

Glipizide is an antidiabetic drug which is used to treat type 2 diabetes. Glipizide belongs to BCS class 2, which have low solubility and high permeability. Due to the solubility problem it has low bioavailability. In this experimental work attempts are made to enhance the solubility of glipizide by mixed solvency technique which consists of cosolvency and hydrotrophy methods. In cosolvency method four cosolvent namely polyethylene glycol, propylene glycol, glycine and ethanol were considered and In Hydrotropy method, three different hydrotropes, sodium benzoate, sodium citrate and sodium salicylate in concentration with % (5, 10, 15, 20, 25, 30, 35 & 40) were used. In cosolvency method PEG was found to be most suitable compare to other three. There was a rise in solubility of glipizide with increase in concentration of PEG but considering its toxic effect 40% of PEG was taken for further concentration. Out of the three different hydrotropes sodium salicylate showed best result with 40%. The monophasic dosages form was formulated and evaluated. The parameters like pH, viscosity, surface tension and specific gravity etc were also performed.

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Keywords

Glipizide, Antidiabitic, Solubility, Cosolvency and Hydrotropy.

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