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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 397) Last page : ( 404)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00072.X

Role of sToll-like receptors 2 and 4 in stage 2 periodontitis patients with and without type 2 diabetes: A randomized clinical control trial

Ramesh Amitha1, Varma Sudhir Rama28, Ramamurthy Srinivas3, Shayeb Maher al28, Shahwan Moyad48, Elkaseh Abed M. Atia28, Khair Al Moutassem Billah58, Mageet Adil28, Arif Madeeha6, Thomas Biju1, Jaganathan Pavithra1, Shetty Suchetha7, Sharmila K.P7

1Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Mangaluru, Karnataka, India.

2Department of Clinical sciences, College of Dentistry, Ajman University, Ajman, U.A.E.

3Department of Pharmaceutical Sciences, College of Pharmacy, University of Science and Technology of Fujairah, Fujairah, U.A.E.

4Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, U.A.E.

5Department of Basic Sciences, College of Dentistry, Ajman University of, Ajman, U.A.E.

6College of Dentistry, University of Science and technology of Fujairah, U.A.E.

7Central Research Laboratory, Department of Biochemistry, K.S. Hegde Medical academy, Deralakattae, Mangaluru, Karnataka, India.

8Center for Medical and Bio-allied health sciences research, Ajman university, Ajman, U.A.E.

*Corresponding Author E-mail: s.varma@ajman.ac.ae

Online published on 22 April, 2021.

Abstract

Objective: The role of TLRs as principal signaling receptors in recognizing endotoxins on gram positive and negative bacteria is facilitated by TLRs and further enhances its role as a potential biomarker in assessing periodontal disease. The study aimed at evaluating the expression of sTLR2 and sTLR4 among healthy, periodontal and diabetic patients and further if there a comparable expression among the TLRs among genders. Material and Methods: Patients were selected according to pocket depth, Clinical attachment loss and radiographic bone loss. Unstimulated whole saliva was collected. sTLR2 and sTLR4 quantification was estimated by ELISA. Comparison of sTLRs between the study groups were performed using ANOVA followed by Tukey post Hoc test. Independent sample t test was used to compare between the genders. (p≤0.05) Result: Expression of sTLR2 was higher among periodontitis patients compared to diabetic patients, this was also evident with relation to genders. sTLR4 showed significant expression among the three groups and also among the genders. Conclusion: The expression of sTLR2 was higher among periodontitis patients compared to diabetic patients. More studies need to be carried out to evaluate TLRs values among genders.

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Keywords

Toll-like receptors, STLR2, STLR4, Type 2 Diabetes Mellitus, Periodontitis.

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