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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 389) Last page : ( 396)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00071.8

Influence of sodium alginate and calcium chloride on the characteristics of isoniazid loaded nanoparticles

Kumar Sumit*, Bhatt Dinesh Chandra**

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Post Box: 38, Hisar-125001, India.

*Corresponding Author E-mail: pharm.sumitdhariwal@gmail.com

**bhatt_2000@yahoo.com

Online published on 22 April, 2021.

Abstract

The main objective of the current investigation was the evaluation of the influence of sodium alginate (SA) and calcium chloride concentration on the characteristics of isoniazid loaded nanoparticles (NPs). Isoniazid loaded NPs were fabricated using the ionotropic gelation technique. The NPs fabricated, were evaluated for average particle size, encapsulation efficiency, drug loading and FTIR spectroscopy along with in vitro drug release. The particle size, drug loading & encapsulation efficiency of fabricated nanoparticles were ranging from 230.7 to 532.1 nm, 5.88% to 11.37% and 30.29% to 59.70%, respectively. Amongst all batches studied, formulation F-8 showed the best-sustained release of drug at the end of 24 hrs.

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Keywords

Tuberculosis, Ionotropic gelation, Nanoparticles, Antitubercular drug, Sodium alginate, Calcium chloride.

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