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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 280) Last page : ( 284)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00050.0

Solubility promotion of telmisartan by solid dispersions using polymer combinations

Reddy Nazemoon1*, Dugasani Swarnalatha2, Nayakanti Devanna3

1Research Scholar, Research and Development, Jawaharlal Nehru Technological University, Ananthapuramu, Andhra Pradesh, India.

2Principal and Professor, Department of Pharmacognosy, Annamacharya College of Pharmacy, Rajampeta, Kadapa, Andhra Pradesh, India.

3Director, Jawaharlal Nehru Technological University-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu, Andhra Pradesh, India.

*Corresponding Author E-mail: nazimoonknl@gmail.com

Online published on 22 April, 2021.

Abstract

This research aimed to prepare Telmisartan solid dispersions with polymer blend [Equal portion of PVP K-30, Poloxamer-188, and (HPMC) K4M. Various ratios of Telmisartan: Polymer blend in the ratios (1: 1, 1: 3, 1: 5 and 1: 7) were fabricated as solid dispersions by melting and solvent evaporation methods, later compressed into tablets. The solid dispersions were tested for physicochemical, and release constraints. The results discovered that the formulations were impressed with the increase in the solubility. Among them formulation with a 1: 5 ratio found to be the best proportion for enhancing the solubility and release rate of Telmisartan from the solid dispersions.

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Keywords

Telmisartan, Polymer blend, Solid dispersions, Solubility.

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