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Year : 2021, Volume : 14, Issue : 1
First page : ( 275) Last page : ( 279)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00049.4

Synthesis, characterization and antifungal evaluation of substituted pyrimidin-2-thione derivatives

Pandey Shradha1*, Pandey Prateek2, Gautam Singh Shekhar2, Singh Jagdamba1

1Environmentally Benign Laboratory, Dept. of Chemistry, University of Allahabad, Allahabad, Uttar Pradesh, India.

2United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India.

*Corresponding Author E-mail: shradha.06@gmail.com

Online published on 22 April, 2021.


Pyrimidine and its thione derivatives have found a wide range of application in medicine due to their pronounced biological activity. An attempt has been made to combine the toxophoric qualities of biologically versatile 2-amino-4-aryl thiazole and 5-arylidene-3-aryl rhodanine moieties and synthesizing pyrimidin-2-thione derivatives, VII(a-j). The compounds were screened for their in vitro antifungal potential against Aspergillus niger and Fusarium oxysporium. The results were promising as the compounds VII b, VII c, VII g and VII h displayed fungicidal action equivalent to that of commercial fungicide Dithane M-45 at 1000 ppm concentration.



Pyrimidine, Thione, Rhodanine, Fungicides, 2-amino-4-aryl thiazole, Agar-plate.


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