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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 270) Last page : ( 274)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00048.2

Graphene synthesis in obtaining a safe particle size in blood circulation system

Wajdi Farid12, Kusumaningtyas Indraswari1, Wijaya Andi Rahadiyan1, Tontowi Alva Edy1*

1Department of Mechanical and Industrial Engineering, Universitas Gadjah Mada, Jl. Grafika 2, Yogyakarta, 55281, Indonesia.

2Department of Industrial Engineering, Universitas Serang Raya, Jl. Raya Serang Cilegon KM.5, Serang, 42116, Indonesia

*Corresponding Author E-mail: alvaedytontowi@ugm.ac.id

Online published on 22 April, 2021.

Abstract

Graphene is an inorganic nanomaterial that is biocompatible and safe in certain concentration. Since it is proposed as drug delivery or scaffold material, the size of the graphene sheets should be considered for the toxicity in the blood circulation. Permanent damage to cell membranes can occur due to the large size of nanoparticles through binding with cellular membrane proteins. Its synthesis process can modify the size of graphene nanoparticles. This paper presents a graphene synthesis from graphite powder that consider particle size change as induced by sonication. The synthesis was conducted by mechanical exfoliation method using a kitchen blender and a water bath sonicator. The study aimed to predict a safe lateral dimension of graphene nanoparticles. The characterizations were performed by X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), Transmission Electron Microscopy (TEM), and Particle Size Analysis (PSA). The results showed that prolonged sonication time had caused defects to the graphene layers. The mean of graphene layers lateral decreases from 2973.7 nm to 655 nm after 120‘ sonication time. We proposed a simple regression model of the sonication time (x) to the lateral dimension change (y) and found that we can obtain to obtain a mean graphene lateral dimension of 40 nm after 146‘ sonication.

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Keywords

Graphene, Synthesis, Exfoliation, Particle size, Safety.

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