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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 245) Last page : ( 248)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00043.3

Formulation and evaluation of miglitol matrix tablets by using Hibiscus rosa sinensis leaves mucilage

Deepika B1, Sujatha K.2*, Thirupathi A. Thanga1, Chamundeeswari D.2

1Nalanda College of Pharmacy, Nalgonda-508001.

2Professor, Faculty of Pharmacy, SRIHER, Porur, Chennai-600116.

*Corresponding Author E-mail: sujamano73@gmail.com

Online published on 22 April, 2021.

Abstract

Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable. In this research, Miglitol Matrix tablets were formulated using Natural Gum extract of Hibiscus rosa sinensis leaves. Miglitol is an antidiabetic drug with less biological half-life of 1.5 hours. The objective behind the research was to delay the Miglitol drug release by matrix formation and allow the drug to get absorbed completely from the intestinal mucosa by using different concentrations of Hibiscus rosa sinensis leaves mucilage. Total four formulations were developed using different mucilage concentrations like 10%, 20%, 30% and 40% w/w. The tablets were prepared by using wet granulation technique and they were evaluated for physicochemical properties like weight variation, friability, hardness, thickness and in vitro drug release. The dissolution studies indicated that the drug release from formulations was sustained up to 18 to 24 hours. The results concluded that the matrix formation in tablets containing 30% w/w of mucilage (optimized formulation) was high and the drug release was extended up to 24 hours. The dissolution data was well fitted into all kinetic models and the drug release data of optimized formulation was well fitted with zero order model and Higuchi equation indicating constant rate-diffusion controlled drug release. This research revealed the importance of a novel natural rate controlling mucilage in the formulation of sustained release matrix formulations.

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Keywords

Miglitol, Hibiscus rosa sinensis leaves mucilage, Matrix, Sustained release and natural polymer.

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