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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 231) Last page : ( 234)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00040.8

Hinguvachadi choornam, an Insilico approach to confirm the therapeutic efficacy towards PCOS

Raj Divya R, Merlin N J*, Dharan Shaiju S

Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Neyyantikara-695124, TVM.

*Corresponding Author E-mail: merlinbinu76@yahoo.co.in

Online published on 22 April, 2021.

Abstract

Polycystic Ovary Syndrome (PCOS) in other way known as hyperandrogenic anovulation. Itis the common endocrinological and metabolic disorder in women of reproductive age which may leads to infertility. The condition estimate by the development of more than 10 small ovarian cysts of diameter ranging from 2-9mm. Disordered gonadotropin secretion in PCOS women leads to increased LH level which disturbs the LH: FSH ratio in body. Stimulation of FSH receptors with plant phytoconstituents elevate the production of FSH which reduce the over activity of LH and reduce the PCOS activity. In addition, inhibition of androgen receptors reduce the excess androgenic activity in body. Hinguvachadi choornam; an Ayurvedic formulation used for treating Poly Cystic Ovarian Syndrome. In the present study, insilico evaluation of FSH receptor (4AY9) and androgen receptor (2PIV) by phytoconstituents present in the choornam were studied using PyRx, PyMOL, Open babel software. ADME parameters are evaluated with SWISS ADME software. The results revealed that all the phytoconstituents possess binding energy ranges from-6.0kcal/mol to-10.0kcal/mol with the two receptors. In addition, the drug likness of the constituents present in the choornam; asarone, ferulic acid, alantolactone, quercetin, naringenin and gingerol predicts through analyzing the ADME properties.

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Keywords

Poly Cystic Ovarian Syndrome, Hinguvachadi choornam, Swiss ADME, FSH receptor, Insilico study.

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