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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 214) Last page : ( 218)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00037.8

Development of validated analytical area under curve UV spectrophotometric method for assay of cetrizine dihydrochloride

Karajgi S.R.*, Metri S.M., Khan Akhtar, Islam Rashidur, Preeti K., Potadar S.S.

Dept. of Quality Assurance, BLDEA's SSM College of Pharmacy and Research Centre, Vijayapur586103, Karnataka, India.

*Corresponding Author E-mail: santosh.karajgi@gmail.com

Online published on 22 April, 2021.

Abstract

A simple and efficient method for the determination and estimation of area under curve of Cetirizine dihydrochloride has been developed using distilled water as solvent. Cetirizine dihydrochloride obeys Beer's Law in the concentration range of 10–30μg/ml at Area of 225nm to 235nm using UV-spectrophotometer SHIMADZU model UV 1800. The method was applied to the tablet formulations and found to be accurate, precise and economic for routine determination of Cetrizine in pharmaceutical dosage forms.

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Keywords

Cetrizine, Analytical method, Area under curve, UV spectrophotometric, Determination.

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