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Year : 2021, Volume : 14, Issue : 1
First page : ( 136) Last page : ( 142)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00024.X

Estimation of temperature effect on PVC-based ciprofloxacin selective electrode response

Sakur Amir Alhaj*, Dabbeet Hashem A., Noureldin Imad

Department of Analytical and Food Chemistry, Faculty of Pharmacy, Aleppo University, Syria.

*Corresponding Author E-mail: profsakur@gmail.com

Online published on 22 April, 2021.


In this work we investigated the effect of temperature variance on the response of the ion selective electrode by investigating the ability of using ciprofloxacin ion selective electrode in a temperature range spreading over 5°C to 60°C, and so determined the optimum range of temperature the ion selective electrode can show near NERNSTIAN response, performing good sensitivity, best LOD and LOQ, widest linearity range, shortest response time, and maximum life time. Temperature variance effect on the response of ion selective electrode was studied according to the response of ion selective electrode by Nernst equation, which (when the ion selective electrode express a near NERNSTIAN response) indicate the perfect sensitivity for the ion selective electrode towards the studied ion comparing to the other ions in the sample. For that, a PVC-Based ciprofloxacin selective electrode was used with CFX-phosphotungestic acid (CFX-PTA) as an electro active material. The characterization and analytical properties were determined, and the casting selective membrane of the selective electrodes was plasticized by di-n-butyl phthalate (DBP). The assembled electrode has an internal reference Ag/AgCl electrode, and an external reference Ag/AgCl electrode. The developed sensors showed near NERNSTIAN response for ion pair percentages of 6%. PVC-Based ciprofloxacin selective electrode could work in temperature range from 5°C to 55°C without any significant change in its parameters, with linear range 10–10000μM of ciprofloxacin, and total measuring range (TMR) 3.16–31623μM over a pH range of 2.0–6.0, both when the temperature is similar between the filling solution of the electrode and the sample solution, and when the temperature is unsimilar between the filling solution of the electrode and the sample solution. Also, LOD and LOQ values were determined. Temperature variance between 5°C and 55°C didn't affect the slope of the selective electrode more than 2.3% which indicate a good sensitivity of the selective electrode in this wide range of temperature. Temperature above 55°C has a destructive effect on the response of membrane. In addition, temperature variance between 5°C and 55°C didn't affect the response time of the CFX selective electrode.



Drug Selective Electrode, Novel Drug selective membrane, PVC membrane, Ciprofloxacin, Potentiometric Determination, Temperature effect on selective electrode.


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