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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 109) Last page : ( 114)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00020.2

Optimization of repaglinide controlled release floating tablet

Kamere Kishore1*, Gopalakrishna S.V2, Subbareddy G.V.3

1Research Scholar, JNTUA, Anantapuramu, Andhra Pradesh, India.

2Vagdevi College of Pharmacy and Research Centre, Brahmadevam (V), Muthukur (M), Nellore Dt.-524 346, Andhra Pradesh, India.

3JNTUA College of Engineering, Pulivendula, YSR Kadapa Dt.-516390, Andhra Pradesh, India.

*Corresponding Author E-mail:

Online published on 22 April, 2021.

Abstract

The aim of present investigation was to develop efficient controlled release floating tablet (CRFT) of Repaglinide. Floating dosage form for gastric retention has potential to use as controlled-release drug delivery systems which providing opportunity for both local and systemic drug action. The tablets were prepared by using wet granulation techniques using PVP K 30, NKG and Carbopol 934 P. A 32 full factorial design (CCD) was applied to optimize two independent variables at three different levels by varied response variables. Two independent variables i.e. amount of NKG (i.e., polymer X1) and amount of Carbopol 934 P (i.e., polymer X2) were varied at three different levels that was coded for low, medium and high (−1, 0, 1 respectively). The response variables T6 (cumulative % amount of drug released in 6 hr) (Y1), T12 (cumulative % amount of drug released in 12 hr) (Y2), Q50 (time in minutes required to 50% of drug released) (Y3), FLT (Y4), TFT (Y5), and Swelling Index after 12 hr (Y6) were selected for present study. ANOVA study was also employed to optimize for best fitted quadratic model. Compressed matrices exhibited Super case-II transport drug release kinetics approaching zero-order, as the value of release rate exponent (n) varied between 0.9430 and 1.0133. Formulation A4 was the optimized best formulation from the response surface plot and contour plot of all the formulation.

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Keywords

Carbopol 934 P, ANOVA, CCD, FLT, NKG, TFT.

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