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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 85) Last page : ( 90)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00016.0

Cell proliferative potential of ethnomedicinal plants for the management of Osteoporosis

Vegad Kunjal*, Kakadia Nimisha**, Kanaki Niranjan***

Sharda School Pharmacy, Pethapur-Mahudi Road, Pethapur, Gandhinagar.

K.B. Institute of Pharmaceutical Education and Research Centre, Gandhinagar, Gujarat, India

*Corresponding Author E-mail: kunjalvegad11@gmail.com

**nimisha1172@gmail.com

***niranjanskanaki@yahoo.co.in

Online published on 22 April, 2021.

Abstract

Osteoporosis is a silent disease leading to complications with the progression in the disease. Osteoporosis is characterized by a decrease in bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. During the early menopausal stage in women, there is reduction in circulating estrogen which leads to an increase in the rate of bone resorption. Hence, there is an imbalance between bone formation and resorption which lead to osteoporosis. Many traditional plants and phytoconstituents have been used as potential therapy for the treatment of the osteoporosis. However, the scientific approach for the validation of the use of phytoconstituents or herbs in the treatment of osteoporosis is the need of an hour. In present work five ethnomedicinal plants, Asparagus racemosus, Hemidesmus indicus, Berberis aristata, Emblica officinalis, and Nigella sativa were selected on the basis of their use in bone diseases in literature. The selected plants were studied for the positive effect on cell proliferation which is one of the important targets for the bone remodeling. Cell proliferative activity of aqueous and ethanolic extracts of selected plants was screened using MTT assay. Osteosarcoma cells (MG-63 cell line) and primary mesenchymal stem cells (MSCs) isolated from the rat femur were used for the MTT assay. The results of the above study showed significant (P < 0.001)cell proliferative activity of aqueous extract of seeds of Nigella sativaon MG-63 cells and MSCs and hence, supporting its ethnomedicinal use in the management of osteoporosis.

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Keywords

Osteoporosis, Ethnomedicinal plants, MG-63 cell line, Mesenchymal stem cells, MTT assay.

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