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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 75) Last page : ( 78)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00014.7

Analytical method development and validation of teneligliptin by UV spectroscopy

Maruthi R1, Chandan R.S.*, Barath M1, Mr. Datta G Naveen2, Ms. D'silva Merryl2, Ms. Kumari Kajal M3, Mr. Ahmad Farhan3, Ms. Geetha R3

1Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Sri Shivarathreeshwara Nagara, Mysuru-Karnataka, India, 570015

2Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Sri Shivarathreeshwara Nagara, Mysuru-Karnataka, India, 570015

3Department of Pharmacy Practise, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Sri Shivarathreeshwara Nagara, Mysuru-Karnataka, India, 570015

*Corresponding Author E-mail: rschandan@jssuni.edu.in

Online published on 22 April, 2021.

Abstract

The measurement of teneligliptin in a drug pure in compliance with the ICH Guidelines, an easy and extraction free UV spectrophotometric method, was developed and validated. At 246nm and linearity of concentration of 10–50μg/ml, the drug shows strong absorption. The process for relaying the drug reaction to MeOH was calculated by its absorption maximum (λmax) 246nm in order to achieve a colorless solution. In the 10–50μg/ml concentration range, the rule on beer complied. The calibration chart was found to be linear, and the coefficient of correlation (r2) was found to be 0.9952%. The experimental value LOD and LOQ parameters for the proposed procedure are measured, respectively, like 2.25 and 6.83μg/mL. Teneligliptin recovery was reported as 101.58%. To maximize the reaction condition, all of the parameters were analyzed.

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Keywords

Teneligliptin, MeOH, Validation, ICH guidelines.

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