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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 62) Last page : ( 66)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00012.3

Development and Validation of spectrophotometric estimation of vildagliptin through Oxidative coupling reaction using MBTH reagent in Pharmaceutical dosage form

Patel Vaishali P.*, Bhatt Krishna A., Shah Mrunali M., Patil Dharti M., Patel Rakshita S., Desai Divya M., Parmar Prachi H.

Department of Quality Assurance, Parul Institute of Pharmacy and Research, Parul University, Waghodia Road-390019, Vadodara, Gujarat, India

*Corresponding Author E-mail: vp42468@gmail.com

Online published on 22 April, 2021.

Abstract

Scientifically estimation of Vildagliptin in bulk and pharmaceutical dosage forms by 3-methyl-2-bezothiazoline hydrazone reagent using longer wavelength give strong absorbance. The purpose of this analytical validation procedure is to validate using ICH guideline.3-methyl-2-bezothiazoline hydrazone reacts with ferric chloride in the presence of amine group, Resulting green coloured species scanned in uv-visible spectrophotometric with the range 400-800nm. Linearity concentration ranges10 to 50μg/ml and it given absorbance at 620nm, Correlation coefficient value 0.998, Recovery studies obtain within range of 98.41 to 99.75% at maximum absorbance 620nm. This method can be successfully applied for the estimation of drug content in pharmaceutical formulations. Resulting Analytical Validate method suitable for its intended use.

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Keywords

3-methyl-2-benzothiazoline hydrazone, Vildagliptin, Ferric chloridespectrophotometric determination, ICH guidelines.

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