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Year : 2021, Volume : 14, Issue : 1
First page : ( 47) Last page : ( 51)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00009.3

Evaluation of Anti-inflammatory and Anti-diabetic activities of Actinodaphne madraspatana bedd leaves

Padmavathy J.1, Venkatachalam T.2, Chandiran I. Sarath3, Raman S. G.3, Rajkumar R.4, Saravanan D.5*

1School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu-600117.

2Annai JKK Sampoorn Ammal College of Pharmacy, Komarapalayam, Namakkal, District, Tamil Nadu-638183.

3School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University, Puducherry-607402.

4Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Thiruvannamalai, Tamil Nadu, India-606603.

5Jaya College of Paramedical Sciences, College of Pharmacy, CTH Road, Thiruninravur, Chennai, Tamil Nadu, India-602024.

*Corresponding Author E-mail: dev.srvana@gmail.com

Online published on 22 April, 2021.


The present study was carried out to find out the in-vivo anti-inflammatory and anti-diabetic activities of ethanol extract (200 and 400mg/kg) of leaves of Actinodaphne madraspatana (A. madraspatana) on Swiss Albino rats. The anti-inflammatory activity was investigated in carrageenan induced rat paw edema model which was compared with standard drug indomethacin at a dose level of 10mg/kg and the parameter measured being the paw volume by mercury displacements at 0, 15, 30, 60, and 120 minutes. The edema was induced in rats by administration of 1% w/v solution of carrageenan in normal saline solution (1%w/v). The anti-diabetic activity was investigated in streptozotocin induced diabetic rat, which was compared with standard drug glibenclamide at a dose level of 4 mg/kg and the parameter measured being the blood glucose level on 0, 7, 14, 21 days. Diabetes was induced in rats by administration of streptozotocin (60mg/kg) in ice cold citrate buffer (pH 4.3). Results of pharmacological activities revealed that the ethanol extract of the plant leaves showed the significant (p<0.001) anti-inflammatory and anti-diabetic activities in a dose of 200mg/kg and 400 mg/kg body weight. The ethanol extract of leaves of A.madraspatana possess the anti-inflammatory and anti-diabetic activities.



A.madraspatana Leaves, Acute toxicity study, Ethanol extract, In-vivo pharmacological activities.


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