(3.236.121.117)
Users online: 1735    [ij] [ij] [ij] 
Email id
 

RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 47) Last page : ( 51)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00009.3

Evaluation of Anti-inflammatory and Anti-diabetic activities of Actinodaphne madraspatana bedd leaves

Padmavathy J.1, Venkatachalam T.2, Chandiran I. Sarath3, Raman S. G.3, Rajkumar R.4, Saravanan D.5*

1School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu-600117.

2Annai JKK Sampoorn Ammal College of Pharmacy, Komarapalayam, Namakkal, District, Tamil Nadu-638183.

3School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University, Puducherry-607402.

4Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Thiruvannamalai, Tamil Nadu, India-606603.

5Jaya College of Paramedical Sciences, College of Pharmacy, CTH Road, Thiruninravur, Chennai, Tamil Nadu, India-602024.

*Corresponding Author E-mail: dev.srvana@gmail.com

Online published on 22 April, 2021.

Abstract

The present study was carried out to find out the in-vivo anti-inflammatory and anti-diabetic activities of ethanol extract (200 and 400mg/kg) of leaves of Actinodaphne madraspatana (A. madraspatana) on Swiss Albino rats. The anti-inflammatory activity was investigated in carrageenan induced rat paw edema model which was compared with standard drug indomethacin at a dose level of 10mg/kg and the parameter measured being the paw volume by mercury displacements at 0, 15, 30, 60, and 120 minutes. The edema was induced in rats by administration of 1% w/v solution of carrageenan in normal saline solution (1%w/v). The anti-diabetic activity was investigated in streptozotocin induced diabetic rat, which was compared with standard drug glibenclamide at a dose level of 4 mg/kg and the parameter measured being the blood glucose level on 0, 7, 14, 21 days. Diabetes was induced in rats by administration of streptozotocin (60mg/kg) in ice cold citrate buffer (pH 4.3). Results of pharmacological activities revealed that the ethanol extract of the plant leaves showed the significant (p<0.001) anti-inflammatory and anti-diabetic activities in a dose of 200mg/kg and 400 mg/kg body weight. The ethanol extract of leaves of A.madraspatana possess the anti-inflammatory and anti-diabetic activities.

Top

Keywords

A.madraspatana Leaves, Acute toxicity study, Ethanol extract, In-vivo pharmacological activities.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
597,751,175 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.