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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 28) Last page : ( 36)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00006.8

In vitro Antioxidant potential and Anticancer activity of Ceratophyllum demersum Linn. extracts on HT-29 human colon cancer cell line

Awati Suhas S.12*, Singh Santosh K.1, Wadkar Kiran A.3

1School of Pharmacy, Suresh Gyanvihar University, Jaipur, Rajasthan, India-302025

2Dr. Shivajirao Kadam College of Pharmacy, Kasabe Digraj, Dist. Sangli, Maharashtra, India-416305

3Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India-416416

*Corresponding Author E-mail: awatiss@gmail.com

Online published on 22 April, 2021.

Abstract

Objective: To decide the phytochemical constituents, antioxidant and anticancer potential of Ceratophyllum demersum Linn. extracts on HT-29 human colon malignant growth cell line. Methods: The whole plant was exposed to Hot Soxhlet continuous extraction with expanding polarity of solvents viz., pet ether, chloroform, ethanol, and aqueous maceration. Phytochemical screening was finished utilizing distinctive phytochemical tests. The antioxidant potential was tried utilizing 2, 2-diphenyl-1-picrylhydrazyl, ferric ion reducing power assay and phosphomolybdenum assay. In vitro anticancer action tried on HT-29 human colon malignant growth cell line and it was assessed by (3-(4, 5-dimethyl thiazole-2yl)-2, 5-diphenyl tetrazolium bromide) MTT test. Results and Discussion: Preliminary Phytochemical screening affirmed the presence of phytoconstituents like alkaloids, flavonoids, glycosides, saponins, sterols, tannins, and reducing sugar. Antioxidant potential was demonstrated most noteworthy in ethanol extracts dependent on the test performed. The ethanol extracts were seen as specifically cytotoxic to HT-29 human colon malignant growth cell line. Conclusion: The outcomes show that Ceratophyllum demersum Linn. was a promising antioxidant; and anticancer agent for HT-29 human colon malignancy cell line. In any case, further examinations are expected to presume that the particular constituent liable for its antioxidant action and cancer prevention agent.

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Keywords

Phytochemical, Antioxidant, Anticancer, Colon cancer, Ceratophyllum demersum.

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