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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4491) Last page : ( 4498)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00792.1

An influence of lyophilization on praziquantel loaded nanosponge's by using food protein as a stabilizer with effect of statistical optimization

Bagade Om M.1,*, Dhole Shashikant N.2, Chaudhari Praveen D.1

1Department of Pharmaceutics, PES Modern College of Pharmacy, Yamuna Nagar, Nigdi, Pune, 411044, Maharashtra, India

2Department of Pharmaceutics, PES Modern College of Pharmacy, Moshi, Pune, 412105, Maharashtra, India

*Corresponding Author E-mail: ombagadescop@gmail.com

Online published on 16 September, 2020.

Abstract

Nanosponges are tiny sponges with a size of a small virus, which can be filled with a wide variety of drugs and can circulate around the body until they stumble upon the specific target site and attach on the surface and begin to release the drug in a controlled and expected manner. Praziquantel is anthelmintic drug which is belong to biopharmaceutical class II drug. There was no interaction found between drug and excipients as revealed by an IR spectra and standard curve of the pure drug and placebo formulation. Nanosponge of different ratios were prepared by emulsion solvent diffusion method by using ethyl cellulose (X1) and PVA/whey protein was used as polymers, dichloromethane (DCM) (X2) as a solvent and Stirring speed (X3) maintained for different batches. These factors were selected as independent variables, while Drug loading, Particle size and cumulative drug release were selected as dependent variables. The whey protein is used as stabilizers. Furthermore, an optimal batch was selected from eight formulations by using 23 factorial design and evaluated for bulk density, tapped density, angle of repose, compressibility Index, Carr's index, dissolution studies, Entrapment efficiency, production yield, compatibility studies, powder x-ray diffraction (P-XRD), Differential scanning colorimetric (DSC), particle size analysis etc. Hence, nanosponge formulation using a variety of polymers was found to be a good alternative approach for increasing the dissolution rate of Praziquantel.

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Keywords

Particle size, Micromeritics, Nuclear Magnetic Resonance, Cumulative drug release, Factorial design, Anthalmintic.

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