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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4323) Last page : ( 4328)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00764.7

Validated uv-visible spectroscopic analytical method development and stability studies on oseltamivir

Sasikala M1,2,*, Mohan S1, Gokilambal V1, Mymoona S1, Hari P1

1Karpagam College of Pharmacy, Coimbatore-641032, Tamil Nadu, India

2Faculty of Pharmacy, Karpagam Academy of Higher Education, Karpagam University, Coimbatore-641021, Tamil Nadu, India

*Corresponding Author E-mail: sasikalampharm@gmail.com

Online published on 16 September, 2020.

Abstract

Aim and Objective

To develop and validate a simple accurate and precise UV-spectrophotometric method to determine the degradation pathway of Oseltamivir in bulk form.

Methodology

Separation of the drug from its degradation product was achieved by UV and scanned between 200-400nm. Oseltamivir was subjected to stress condition such as acid hydrolysis, alkali hydrolysis, oxidation, photolysis and thermal degradation. The samples were analyzed.

Results

The maximum absorbance was found at 216nm and found to be linear over the range of 5–30μg/ml with good correlation co-efficient 0.999. Major degradation was observed in photolysis, oxidative and alkali degradation.

Conclusion

The UV spectrophotometric method for Oseltamivir in the bulk form was developed and validated.

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Keywords

Oseltamivir, Stress condition, Stability, Cost effective method.

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