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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4274) Last page : ( 4276)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00754.4

Metoprolol induced oral lichen planus in an adult female patient - a case report

Pargi Piyushkumar M.1, Purohit Bhargav M.2, Hadiyel Lla N.2, Roy Tathagata3,*, Mukhopadhyay Debraj4, Ghosh Somsubhra5, Paul Susanta6

1Department of Pharmacology, Government Medical College, Bhavnagar-364001

2Associate Professor, Department of Pharmacology,Government Medical College, Bhavnagar-364001

3Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109

4School of Allied Health Sciences, Delhi Pharmaceutical Sciences and Research University, (DIPSRU), New Delhi

5Assistant Professor, Department of Pharmaceutical Technolog, NSHM, Knowledge Campus, Kolkata-Group of Institution, 124, B. L. Saha Road, Kolkata-700053, W.B.

6Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109

*Corresponding Author E-mail: troy@jisuniversity.ac.in

Online published on 16 September, 2020.


The prevalence of oral lichen planus (LP) in Indian population is 2.6% with more female predilection. LP is considered idiopathic but there are anecdotal reports of various medications like β-blockers, nonsteroidal anti-inflammatory drugs (NSAIDs), methyldopa, penicillamine, quinidine, quinine and angiotensin-converting enzyme (ACE) inhibitors.Metoprolol is rarely being reported to cause oral lichen planus despite its common usage. A 25 years old female patient developed bilateral oral lichen planus after administration of metoprolol, which was given for treatment of postpartum dilated cardiac myopathy with atrial fibrillation. Diltiazem was prescribed in place of metoprolol and patient was improved. Increased awareness of prescribers, close monitoring with immediate withdrawal of the culprit drug can reduce the complexity of management that occur due to development of such adverse drug reaction.



Metoprolol, Beta blockers, Oral lichen planus.


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