Formulation development and In vitro characterization of solid lipid nanoparticles of felbamate
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Felbamate is a PE Gylated phenylcarbamate derivative that acts as an antagonist of NMDA receptors. It is used as an anticonvulsant, primarily for the treatment of seizures in severe refractory epilepsy. It is slightly soluble in water with t 1/2 of 4–6 hours. Felbamate loaded solid lipid nanoparticles (SLN) have been developed using placket and burman design of experiments. SLN's were prepared by microemulsion technique. Based on preliminary experiments and on literature, the influence of independent variable parameters selected were lipid (X1), surfactant (X2), and co-surfactant concentration (X3), aqueous phase volume (X4),magnetic stirrer rate (X5), probe sonication duration (X6), volume of beaker used for sonication (X7), volume of cold aqueous phase (X8) on the dependent variable such as particle surface area (Y1) was studied. Other parameters, i.e., magnetic stirrer rate and probe sonication duration were not having a significant impact on particle size and their levels were kept constant for all the experiments. Magnetic stirrer rate has an impact on particle size and was included in the design. It was concluded from the study that the composition prepared with lipid concentration of 50mg, surfactant concentration of 75mg, Co-surfactant concentration of 0.75ml, aqueous phase volume of 5ml, magnetic stirring speed of 400rpm, probe sonication duration 30 minutes, volume of beaker used for sonication 500ml and volume of cold aqueous phase 30ml has shown the highest surface area of 51.9m2g-1.
Solid Lipid, Nano Particles, Particle Size, Sonication, Felbamate.