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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4115) Last page : ( 4124)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00727.1

In vivo study of insulin-loaded microemulsion topical gel with aloe vera for the treatment of dermatologic manifestation of diabetes

Chakraborty T1, Gupta S1,*, Saini V2

1Department of Pharmaceutical Science, M M College of Pharmacy, Maharishi Markandeshwar University, (Deemed to be University), Mullana, Ambala, Haryana, 133207, India

2Department of Pharmaceutical and Medical Sciences, Maharishi Markandeshwar University, Solan, Laddo, Himachal Pradesh, 173229, India

*Corresponding Author E-mail: sumeetgupta25@gmail.com

Online published on 16 September, 2020.


Insulin is useful for the treatment of diabetes mellitus. Because of its high molecular weight, it is difficult to permeate through transdermal routes. There is no existing formulation available for the dermatologic manifestation of diabetes. Thus an attempt was made to prepare insulin-loaded microemulsion topical gel with aloe vera. The insulin-loaded microemulsion was prepared using 3 square factorial design, using oleic acid as oil phase, tween-80 as the surfactant and poly ethylene glycol-400 as co-surfactant. Physical stability studies performed and amongst all of them, the best three formulations selected for ex vivo insulin permeation study. The batch with the best permeation was selected to prepare the topical gel with and without aloe vera. Post evaluation parameters of topical gel with skin irritation study and in vivo study performed. In vivo study results revealed that the groups of diabetes Wistar albino rats with skin infections; by the treatment of topical gel of insulin-loaded microemulsion with aloe vera gel was found to reduce the blood glucose level and skin infection as compared to one without aloe vera gel. It was concluded that insulin loaded microemulsion topical gel with aloe vera can be used as dermatologic manifestation of diabetes significantly.



Diabetes dermopathy, Dermatologic manifestation, Topical gel, Microemulsion, Insulin, Aloe vera gel, Skin infection.


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