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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4051) Last page : ( 4054)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00716.7

Cytotoxic and apoptotic effect of citrus flavonoid naringin in treating pa-1 ovarian cancer cells

Jarrett Nebita Maria, Gloria Jemmi Christobel R., Abirami M.P., Shyam Sundar J., Radhakrishnan S., Deepa S., Abirami S., Shila S.*

Department of Biochemistry, VRR Institute of Biomedical Science, (Affiliated to University of Madras) Chennai, Tamilnadu, India

*Corresponding Author E-mail: shilasamuel72@gmail.com

Online published on 16 September, 2020.

Abstract

Ovarian cancer is one of the leading deadliest cancers among women and new therapeutic options with lesser side effects are in urgent need. Naringin is a citrus flavonoid recently studied for anti-cancer activity in numerous cancer cells. Evasion of apoptosis is the hallmark of cancer and therefore we investigated the potential of naringin to induce anti-proliferative and apoptotic effects in PA-1 ovarian cancer cells. Trypan blue assay and Western blotting techniques were employed on the treated and untreated PA-1 cells for anti-proliferative and apoptosis analysis. Naringin effectively reduced viability of PA-1 cell line. Immunoblot analysis revealed marked changes in the upregulation of pro-apoptotic markers like Bax and Caspase-3 along with downregulation of anti-apoptotic marker Bcl-2. Taken together, our results suggest that treating naringin may offer a new therapeutic strategy to improve the survival rates of ovarian cancer patients.

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Keywords

Naringin, Apoptosis, Ovarian cancer, Anti-proliferation.

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