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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 4023) Last page : ( 4027)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00711.8

Hydrogels for cancer drug delivery

Naik Swathi1, T Vamshi Krishna1, Nayak Abhinaya1, Joshi Mahendra2, K Girish Pai1,*

1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka State, India-576104

2IDRS Labs Pvt Ltd, Bengaluru, Karnataka State, India

*Corresponding Author E-mail: girish.pai@manipal.edu

Online published on 16 September, 2020.

Abstract

Developing the assurance and potency proportion of actual chemotherapeutic medicament is an ongoing task that needs to be worked upon hand in hand with development of new chemotherapeutics agents that require a great deal of time and cost. Hydrogels have emerged as promising drug delivery systems which can efficiently provide both contiguous and sensual control over the discharge of numerous therapeutics. They have also found use in contact lens manufacture, cosmetics, hygienic products, wound healing. In addition to facilitating building up organoids and organ on a chip of hydrogels have thus become an important issue as drug delivery systems for chemotherapeutics. This review emphasis on the mechanisms of hydrogels, mechanism of hydrogel formation, their types and applications of various hydrogels as a delivery system for chemotherapeutic agent. Studies had made tremendous advances in reconstruction of the tumor form, tumor treatment and related therapies due to the special properties of hydrogels. Notably, it is possible to adjust hydrogel-based devices to react to internal stimuli specific to cancer. Such well-known medicament storage is adopted as intelligent transports for various cargoes, namely chemotherapeutics, genes, and radioisotopes, both bare and nanoparticle-encapsulated. Hydrogels can provide spatial and temporal influence over the discharge of several biomedical products, along with medicines for small molecules, macromolecular drugs and cells.

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Keywords

Hydrogel, Cancer, Drug delivery system, Chemotherapy, Types of hydrogel.

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