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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3999) Last page : ( 4001)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00707.6

PRSS-1 gene mutations in etiopathogenesis of pancreatic cancer

Nirenjen S1, Praveen D2, Chowdary P Ranadheer2, Vijey Aanandhi M3,*

1Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India

2Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India

3Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India

*Corresponding Author E-mail: hodpchemistry@velsuniv.ac.in

Online published on 16 September, 2020.

Abstract

The genetic which alters the PRSS-1 (protease serine-1) gene results in chronic pancreatitis, which further causes pancreatic cancer. The equilibrium of the protease and anti-protease is altered by the RI22H (A sub-mutation of PRSS-1) which promote the onset of pancreatic cancer. Gene conversion is the major phenomenon which create the nucleotide changes that affect the axon part of thePRSS-1 gene. Genetic factors, Alcoholism, smoking, lack of the anti-oxidants were some of the factors, which causes the PRSS-1 gene mutations.

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Keywords

Mutation, Gene conversion, PRSS -1 gene, Pancreatic cancer.

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