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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3918) Last page : ( 3928)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00694.0

Formulation approaches for solubility enhancement by using polar or non-polar lipid components of bcs class ii drugs through lbdds

Sharma Aditya1,*, Rastogi Vaibhav2, Kumar Prevesh2, Prasad Neelkant3

1School of Pharmaceutical Sciences, IFTM University, Moradabad-244102, Uttar Pradesh, India

2Pharmacy Academy, IFTM University, Moradabad-244102, Uttar Pradesh, India

3SGT College of Pharmacy, SGT University, Gurugram-122505, Haryana, India

*Corresponding Author E-mail: adi99463@gmail.com

Online published on 16 September, 2020.

Abstract

At present, Lipid based preparations such as self-emulsifying, self-microemulsifying and self-nanoemulsifying drug delivery systems are reconnaissance in various treatment as a powerful methodology for improving the biocompatibility, bioavailability and disintegration pace of Biopharmaceutics Classification System Class II drugs. These details manages various preferences likewise decrease in food impact and between individual abnormality, effectiveness of preparations and the likelihood of assembling utilizing basic excipients realistic in the market. These preparations are essentially produced and physically unchangeable blends of oil, surfactants, co-surfactants and solubilized drugs that may regulated orally. These arrangements may also a financially conceivable approaches to articulate various pharmaceutically appropriate dosage forms with respect to topical, oral, pulmonary, or parenteral distribution. Present studies recommend a taxonomic outline of lipid-based systems and their mechanisms required to extend the dissolvability and bioavailability of inadequately water soluble drugs as like Aceclofenac, Gliclazide, Glibenclamide, Glimipride, Ketoconazole and so forth. Few constituents of lipid-based distribution can be used like Soya lecithin, Olive oil, Soyabean oil, Poloxomer, Tween 80 etc. specifically for oral delivery because of their physicochemical and biopharmaceutical viewpoints with their real effective characteristics. Additionally, this review also emphases about the methods can be utilized to get ready such conveyance delivery systems.

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Keywords

Self-emulsifying drug delivery systems, Self-micro emulsifying drug delivery systems, Self-nano emulsifying drug delivery systems, Biopharmaceutics Classification System, Bioavailability, Gliclazide, Soya Lecithin, Soyabean oil.

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