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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3879) Last page : ( 3882)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00686.1

Placental histological on preeclamptic rats (Rattus norvegicus) after administration of nanoherbal haramonting (Rhodomyrtus tomentosa)

Irianti Evi1, Ilyas Syafruddin1,*, Hutahaean Salomo1, Rosidah2, Situmorang Putri C.1

1Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia, 20155

2Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia, 20155

*Corresponding Author E-mail: syafruddin6@usu.ac.id

Online published on 16 September, 2020.


Preeclampsia (PE) can trigger trophoblastic from the placenta into the mother's blood so that it affects the fetus. Extra virgin olive oil (EVOO) containing antioxidant or tocopherol (Vitamin E) and Haramonting is traditional medicine in Indonesia and to treat various diseases, prevent DNA damage, and have antioxidant activity. The aimed of research to determine the role nanoherbal haramonting on placental PE. This study used an animal model of preeclampsia with an injection of 3ml Nacl 6%. This research consisted of: C-: Normal pregnancy rats, C+: PE, T1: PE were given EVOO, T2: PE were given nanoherbal haramonting, T3: PE rats were given a combination of these two herbs. On the 20th pregnancy day the rats were dissected to take the placenta. Histology of placental tissue using paraffin method with hematoxylin eosin staining. Results: There were significant differences in the blood pressure of systol, diastole and proteunaria in each group (P <0.05) so that 6% NaCl could be used in making animal models of PE and the number of tropoblasts in the placenta of PE was a significant difference (P <0.05). Conclusion: Administration of EVOO and nanoherbal haramonting can improve trophoblast counts and placental histology.



Nanoherbal, EVOO, Rhdomyrtus tomentosa, Trophoblast, Placental.


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