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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3854) Last page : ( 3860)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00682.4

Development and evaluation of oral controlled release tablets of oxybutynin using various polymers

Ravi G.1, Bose P. Subhash Chandra1,*, Ravi Valluru, Sarita Damineni2, Reddy P. Srikanth1, Kanna Sandeep1

1Department of Pharmaceutics, MNR College of Pharmacy, Sangareddy-502294, Telangana State, India

2Department of Pharmaceutics, Sultan-ul-Uloom College of Pharmacy, Hyderabad-500034, TS, India

*Corresponding Author E-mail: penjurisubhash@gmail.com

Online published on 16 September, 2020.

Abstract

The aim of the present study was to develop controlled release formulation of Oxybutynin to maintain constant therapeutic levels of the drug for over 12 hrs. Karaya gum, Acacia and Tragacanth were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F4) showed better and desired drug release pattern i.e., 98.14% in 12 hours. It contains the Acacia polymer. It followed Zero order release kinetics mechanism.

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Keywords

Oxybutynin, Karaya gum, Acacia and Tragacanth, Controlled release tablets.

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