Application nanoemulsion of beta carotene in the mucoadhesive patch Tris Harni Pebriani1,3, Shantiningsih Rurie Ratna2, Martien Ronny1,* 1Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia 2Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia 3Yayasan Pharmasi College of Pharmacy, Semarang, 50193, Indonesia *Corresponding Author E-mail: ronnymartien@ugm.ac.id
Online published on 16 September, 2020. Abstract Beta carotene applied to the mucoadhesive gingiva patch was not significantly reduced the micronucleus as the negative effects of panoramic radiographic exposure on patients dental examination. Its solubility in the patch matrix was very low. Development of beta carotene nanoemulsion using combination of Rice Bran Oil (8%), Tween 80 (85%) and PEG 400 (7%) is expected to increase the solubility that dispersed into the mucoadhesive patch preparation. Beta carotene nanoemulsion mucoadhesive patches produced has a weight 91.0 ± 0.2 mg; thickness 0.18 ± 0.01 mm; folding endurance more than 300 times; maximum swelling 120.07 ± 5.28% at 10 minutes; and patch surface pH 6. The amount of beta carotene that dispersed into the patch matrix increased up to 14.39 ± 0.52 μg/4 cm2. The patch stuck to the rabbit palatal mucosa in 44.64±4.24 minutes and its released beta carotene across cellophane membranes by 19.7 ± 1.74% in 8 hours. SNEDDS formulations could increase the amount of beta carotene that dispersed into the mucoadhesive matrix carotene nanoemulsion patch and released beta carotene across the cellophane membrane following the Korsmeyer-Peppas kinetics and the mechanism of Fickian release. Top Keywords Beta carotene, Nanoemulsion, Mucoadhesive patch, Korsmeyer-Peppas. Top |