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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3843) Last page : ( 3848)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00680.0

Studies on inclusion complexes of 2-p-anisilidienyl 3-(benzothiazolyl-2’) hydrazono-5-p-anisilidiene-4 thiazolidinone with β-cyclodextrin

Dash Simanchal*

Department of Chemistry, Roland Institute of Technology, Berhampur, Odisha, India

*Corresponding Author E-mail: dash.simanchal73@gmail.com

Online published on 16 September, 2020.

Abstract

The compound 2-p-anisilidienyl 3-(benzothiazolyl-2’)hydrazono-5-p-anisilidiene-4 thiazolidinone has been synthesized by taking 2-hydrazino benzothiazole as a starting material. Regrettably the compound has poorly soluble in aqueous solvent. Consequently its inclusion complex is build up by taking β-cyclodextrin. The physical and spectral characteristics conforms formation of inclusion complex. Although different methods available for the preparation of inclusion complexes, but co-precipitation method is used here. Phase solubility diagram is constructed for selection of 1:1 stoichiometric ratio between compound and β-cyclodextrin. The free energy of activation and thermodynamically permittivity of the compounds predicts stability of the complexes.

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Keywords

Phase solubility, Co-precipitation, Inclusion complexes, 2-Hydrazino benzothiazole, Thermodynamic stability.

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