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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3777) Last page : ( 3780)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00668.X

Development and validation of uv-spectroscopic methods for simultaneous estimation of hydrocortisone and iodoquinol in tablet dosage forms

Naik Ramavath Mohanbabu1,*, Ahmed Syed2, Kumar S. Vijay3, Radhika K.4, Kumar K. Vinod5

1Asst Professor, Department of Pharmaceutical Analysis and Quality Assurance, Gland Institute of Pharmaceutical Science, Kothapet (V), Near Narsapur, Medak (District), Telangana-502334

2Asst Professor, Department of Pharmaceutics, Gland Institute of Pharmaceutical Science, Kothapet (V), Near Narsapur, Medak (District), Telangana-502334

3Asst Professor, Department of Pharmacognosy, Vishnu Institute of Pharmaceutical Education and Research, Narsapur (Mandal), Medak (District), Telangana-502334

4Asst Professor, Department of Pharmacology, Gland institute of Pharmaceutical Science, Kothapet (V), Near Narsapur, Medak (District), Telangana-502334

5Associate Professor, Department of Pharmaceutical Analysis and Quality Assurance, Raghavendra Institute of Pharmaceutical Education and Research, Krishnam Reddy Pally (V), Ananthapuramu-515721, Andhra Pradesh, India

*Corresponding Author E-mail: mohanbabu623@gmail.com

Online published on 16 September, 2020.

Abstract

A simple, precise, accurate and economical UV-Spectrophotometric method has been developed and validated for the simultaneous estimation of Hydrocortisone and Iodoquinol in combined pharmaceutical dosage form using simultaneous equation method. Hydrocortisone has absorbance maxima at 245nm and Iodoquinol has absorbance maxima at 250nm in Methanol. The drugs obeyed beer's law in the concentration range of 10–60μg/ml for Hydrocortisone and 5–30μg/ml for Iodoquinol. The correlation coefficient of Hydrocortisone and Iodoquinol was found to be 0.999 and 0.999 respectively. The method was statistically validated as per the ICH guidelines. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The developed method was simple, precise, accurate, reproducible and economical which can be efficiently and easily applied to pharmaceutical dosage form.

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Keywords

Hydrocortisone, Iodoquinol, UV-Spectroscopic method.

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